I am really enjoying Fallout 4 and haven't really found any terrible bugs or issues, although the PC interface and keyboard configuration stinks (especially when building a settlement)
However two things really bug me which I hope Bethesda fixes soon.
1. Getting Rid of dead bodies - I am tired of passing the dead raider in his underwear (unfortunately I robbed him early) laying in the road near the bridge to Sanctuary. No matter how many times I have tossed him in the river, he mysteriously reappears on the road.
2. Sending Companions home -- When I change companions, I don't want them cooling their heels at my Red Rocket Workshop, I am sure they would like to get on with their life when not out scavenging with me. Can't we just send them back to their original location until we need them again? At least let me send them to my house in Diamond city.
Just my two cents worth.
Storm