At the moment, I'm going completely natural, but gave up on that when I had to build a circular glass dome. I edited in unlimited glass blocks, and that made the process much faster. I mean, I gave up on making glass blocks after I made 10 of them, and I needed around 500 or so.
Materials such as rocks are a different story though, with my chests bursting to the seam with them, so I just use them up.