It depends on the options you selected when you installed frans, :ie if you selected MOBS combat mod then you need to use unofficial patches that have been modified with MOBS stats or you will lose the changes, other then that, they are compatible, just make sure your load order is right.
Patches for Frans 4.5b:
http://www.tesnexus.com/downloads/file.php?id=17621
Ok so I installed Fran's with Mobs and I just installed all the patches yet now when I try to move backwards it freezes up for a few seconds then moves me a little more then freezes up and so on.
Oblivion.esm
Dark Seducers.esm
CM Partners.esm
Aanila.esm
Francesco's Optional New Items Add-On.esm
Francesco's Leveled Creatures-Items Mod.esm
Francesco's Optional New Creatures Add-On.esm
DLCShiveringIsles.esp
Knights.esp
Francesco's Optional Leveled Quests-SI only.esp
DLCThievesDen.esp
DLCMehrunesRazor.esp
DLCVileLair.esp
DLCBattlehornCastle.esp
Unofficial Oblivion Patch.esp
Unofficial Shivering Isles Patch.esp
Knights - Unofficial Patch.esp
DLCVileLair - Unofficial Patch.esp
DLCMehrunesRazor - Unofficial Patch.esp
DLCThievesDen - Unofficial Patch.esp
DLCBattlehornCastle - Unofficial Patch.esp
RingwraithArmorDaedric.esp
Francesco's Optional Files.esp
Francesco's 10 days respawn time - 1-24 day lenght rescale.esp
MOBS.esp
MOBS Optional Combat Settings.esp
MOBS SI.esp
MOBS SI Optional Combat Settings.esp
Francesco's Slower skills x1.5.esp
eyja.esp
DBShadowSet_Argonian_NE.esp
ASlof'sBraceletsandClaws.esp
M.O.E. - Lycanthropy and Lichcraft.esp
Sauron_Armor_Chest.esp
MaleBodyReplacerV3.esp
TFF_Races_Base_RSM.esp
TFF_Armor_Base.esp
TFF_Clothing_Base.esp
TFF_Clothing_SI.esp
Shadow Steed Nightmare.esp
Dark Seducers.esp
Shadow Steed.esp
MountainTower.esp
tda_ScytheModv1.2.esp
Aanila.esp
CM Partners.esp
Tails_Under_Robes V1_0.esp
ElaborateEyes.esp
Natural_Vegetation_by_Max_Tael.esp
Natural_Habitat_by_Max_Tael.esp
Brighter_Torches.esp
Natural_Weather_with_darker_Nights_by_Max_Tael.esp
There's the load order from OBMM. I used the .exe installer for the Unofficial oblivion patch then, extracted the meshes, sounds and textures from the manual versions of the UOMP and the USIP then used the Frans optional leveled quests SI only patch, the Mobs 1.2.1 standalone, the UOMP 1-5 mobs the UOP 3.2.0 mobs only, the UOP frans optional quests patch and the USIP MOBS 1-4 from the link you gave me.
I think I mustve only messed up with something having to do with movement, did I do everything else right? Any help would be greatly appreciated.