I would like to be able to use "mouse wheel down" and "mouse wheel up" for selecting particular abilities, however it doesn't seem to work. It works fine if I assign them to a keyboard button. Any way around this?

are you unbinding MWHEELDOWN and MWHEELUP before you rebind them or doing it in a autoexec ?

I'm just assigning them in the normal control settings screem. They are not bound to anything else there.

I have the same issue, bound them using the in game option.

I tend to use my mouse wheel down for my melee in other games, so binding it elsehwere is tough to remember now hehe.

they're default to weapprev and weapnext I believe

Well I've tried unbinding them via the console and then binding them via the settings menu and it still doesn't work. It does show up in the in-game hud that MW-D and MW-U are my ability buttons, so that much does work

Thanks for the help.

Problem still persists with the latest update. A quick search of google shows that a lot of people are having this problem. Haven't found a solution yet. You there Bethesda?