The suggestion for a block is based on a recent restart of the game - with several big quest mods. One adds a character who tells me I need to save the Heir first ... another had a starting character who was desparate to get into the tutorial dungeon to get me to help, and a third got mis-triggered and spawned a stray Xivali who promptly got killed off. Setting up some kind of block means your mod automatically becomes more compatible with any others, as nothing can start until YOU choose to let it.
For a similar reason, I always use SM Plugin Refurbish - not for mke the heap of keys, notes and information as I enter the sewers in the tutorial. I have to actually go looking for the DLCs now...