Just a problem I've been getting recently. If I change the camera angle while somebody is speaking the volume they are speaking at changes. I've tried changing the system settings but nothing seems to work.

What is your speaker set-up? Seems like positional audio routing to a speaker that doesn't exist.

As Didact^D say, what's your speaker setup ???

Also try to change your Xbox audio settings to stereo, from 5.1 or vice versa.

I don't have external speakers, just the Xbox 360 and the TV.