Of course, no matter what tone you imagined in your head, the NPC was responding to the tone that the game's writers were thinking. Submissive, aggressive, neutral, blisteringly sarcastic - sorry, the NPC is just going to respond the same way no matter what your inner voice is projecting.
And this is a big part of it, really. Personally, every game I've ever played has been "some character I control". Which is why I have no problem with isometric third person party-based games, over-the-shoulder third person games, first-person games, tabletop pen-and-paper RPGs.... there's no horribly fragile "immersion" to break, because it's always been my character (not "me") that I'm controlling from my chair, from an outside perspective.
(I've always been content to "play the game", too. No, it doesn't bother me that I'm so horribly constrained by Skyrim forcing me to be the Dragonborn.... of course it does, I'm playing Skyrim. I can be good, bad, an archer, a mage, a fighter, all sorts of options. But they're all the Dragonborn, and why not? That's the game. All my FO3 characters have been the Lone Wanderer, all my FONV ones have been the Courier, and all my FO4 ones will be the Sole Survivor. No big deal.)
But hey, that's just me. Different people, different opinions.
(until, of course, those opinions turn to labeling everyone who doesn't have the exact same standards as "masses of simpletons". )