It appears that changing the timescale from the default can break AI packages in NV. Examples are all over the place, Parker killing Keith in the Aerospace office park, the Boomer museum history speech and Lily's test of the SteatlhBoy Mk II are couple of examples. When the glitch hits, the AI script seems to freeze up leaving the NPC stuck in whatever action they were in when the glitch occurred, and it's completely repeatable, these glitches will always occur at these points.
I haven't done any testing to determine if there are break points of timescale where these glitches happen, but certainly with a timescale of 1 they happen universally.
It's very easy to work around, particularly if you use a mod such as Imp's - just switch to static/30 before you trigger the script, and switch back to what you want once it's done, but I think it's worth knowing that if you are getting weird bugs with "stuck" or non-responsive NPCs this could be your cause.