Alright well heres the glitch I came across. Certain weapons ( lever action shotgun, cowboy repeater, trail carbine, hunting shotgun ect..) seem to be glitched out after reloading. If you move while reloading these guns it makes you unable to shoot, VATs, or switch weapons for about 3 seconds. The guns affected seem to be the ones you have to individually load each bullet. I think this may be due to the fast reloading perk screwing something up. ( I have this perk and read through some other posts that had this problem with the same perk)
edit: I take back the part about rapid reload being the problem. I made a new character to test it out and the .357 still locks up and you can't shoot. Hopefully this gets fixed considering the large amount of weapons that are made frustrating to use because of it.