I thought James couldn't drink alcohol or he'd die...
nope, don't renember saying that :shakehead: and anyway he got drunk at the Dinner (one were Brandy arrived)
what he can't take is Drugs, like Pyscho, Jet, Med-x, Rocket and Buffout bascially all of Bad Drugs that increase/decrease someone heart rate... (alcohol, stimpacks, mentats, per-war painpills etc: don't do this)
edit: Note even if he does he's not going to die on spot. In some cases like the "Turth serum"( which if I recall didn't have Jet in it) will unaffect him were as in others ( like one I have planned) he's going to have a heart attack!!!