See my sig for my rig's specs.
For a "monitor", I use my new Samsung 55" 9000 Series Curved UHD 4k TV connected via an Audioquest "Cinnamon" HDMI cable (for video only).
For "audio", I run off my PC with an Audioquest "Cinnamon" optical cable into a Mobile Fidelity "V90-DAC" digital/anolog converter, then via a pair of DH Labs "Silversonic" interconnects (silver conductors) into a Music Hall "Ph 25.2" dedicated tube headphone amplifier. I listen with Sennheiser "HD 650" headphones.
I play with my ass parked in a comfy futon using a wireless 360 Controller, and with a wireless keyboard and mouse as an option.
I'm currently running several texture replacers @1920x1080 capped @ 60FPS with zero stutter/framerate loss. Plan on playing around w/ pushing my resolution much higher.
Also happy to report after several hundred hours of Fallout 4, I've not experienced a single CTD=) *knocks-on-wood*
Probably more info than you asked for OP, but, wth...