So would you recommend going for all the mods on the hunting rifle? Instead of Paciencia? I hear you can't mod unique weapons.
I'mma be really blunt, but I actually think Paciencia is a wasted weapon.
Don't get me wrong, it's VERY powerful. The problem is though that the GRA AMR can do everything Paciencia does, and it can do it better. They have the same cost, serve the same purpose, but the GRA AMR has better damage.
The -ONLY- benefits Paciencia has over the GRA AMR is that:
1) GRA AMR requires 8 STR and 100 guns skill, so it's definitely not a gun you rush to get, because you simply CANNOT use it properly until you get your guns skill up.
2) .308 is cheaper and easier to find than .50
Still, even the cost of the gun itself is bleh. It's like the same cost as the GRA AMR itself...
Like I said, Paciencia is a powerful weapon in it's own right, but I question if it's very....economical. It's a huge investment for a weapon that, yes, you will someday replace. In MY Opinion, it's a rare instance of a gun that's simply inferior to it's competition to the point where it's not even an argument. Could've been good, but they slapped the giant pricetag on it...
You could switch to unarmed for weaker enemies in order to save ammo but I wouldn't rely on it as a main skill nor put any perks in it.
Why not? Unarmed is absolutely devistating as a skill. You reach a point where -THE- moment someone's within arm's reach of you, they're toast. The playstyle takes some adjusting to (don't just go "herp derp i run at u and kill u"), but it's VERY effective as a playstyle. My dead-is-dead Legionnaire (relied on Ballistic fist as his main weapon) outlived my dead-is-dead NCR soldier (basically had the best gun of every category) by a longshot. The only places Unarmed definitely falls behind is Old World Blues (do NOT approach the boss characters with a fist, you WILL die) and to a much more obvious extent, Lonesome Road.
Having said that, you definitely wanna invest perks in unarmed if you choose to exploit it, so that's something to think about: do you have perk space for it? For the record though, my Dead-is-Dead playthrough of the Courier was successful, and the Courier exploited unarmed fairly regularly, but only invested in Piercing Strike and Paralyzing Palm. Piercing Strike made enemy DT a non-issue so I could always do full damage (which is devistating with end-game fists, especially with the Heavy Handed trait), Paralyzing Palm gave unarmed a strategic use. Those two alone meant it was almost ALWAYS beneficial for me to pull out my fist if someone got too close, as a round of VATS was bound to either kill them (Piercing Strike, my crit rate, and Mysterious Stranger/Miss Fortune) or stun them (Paralyzing Palm, Miss Fortune).