I don't think there had to be a cause for the split. It's not an alternate timeline created from the perspective of "what would the world look like if we changed this and that from our own timeline", but from the one of "how did the people in the 1950s imagine the future would look like".
I think that is probably close to the truth, when creating the world for Fallout I don't think the designers asked themselves "What would the world be like if [insert event here] went differently?" It's more like "What would the world look like if the future ended up how people in the 1950s might have envisioned it, and then got blown up by nuclear war?" That also explains why science even works differently, or should I say "Science!"?
Therefore, the split is not caused by a specific, definite event, things as a whole just worked out a bit differently from in real life.