I'd like to see a game set in/around Charleston, West Virginia or Detroit, Ohio or Knoxville, Tennesee or Savannah, Georgia.
I would also like to see a post-apocalyptic game set after a great nuclear war set in, respectively; Russia, the Balkans, India, South Africa, Argentina and Australia. But not with 'Fallout' anywhere in the title.
It would be better to make a separate setting and start with a clean slate for a game like that.
I admit though, the Rad Roo idea is awesome.