Ever since playing "The Replicated Man" mission and hearing about the Commonwealth and the Institute and their astonishing technological achievements (sentient artificial life), I've wanted the next game OR even just a piece of DLC to feature this area.
Other places I'd like:
New York City .... the different atmospheres of different post-apocalyptic boroughs. Perhaps the boroughs are internally unified but fight amongs each other .. Manhattan at war with Brooklyn over resources etc .... secret raids into rival boroughs ... the NYC subway to explore ... skyscraqers, monuments, apartments ... the possibilities are endless.
Tokyo ... for much the same reasons
Los Angeles ... for the sheer sprawing madness of it all.
One of my favourite ideas: Rome. Imagine all the famous landmarks and architecture, half-destroyed .... the ruins of the Coloseum ... descending into the catacombs which are inhabited by mutant nasties. Hiding from our enemies in the Roman Forum.
Or ... turn the camera around and look at it from China's point of view. Surely the US managed to fire a few nukes at China before getting hit by China themselves?? Imagine a ruined Beijing with the Forbidden City to explore. Towering mountains, paddy fields, small villages. Mutated tigers!!!!!!!!!! Communist propaganda everywhere, to mirror the capitalist propaganda in Fallout 3. Survivors wondering if the US is just a myth, just like a NPC wonders about China in Fallout 3.
Maybe I've thought too much about this.