What setting [menu, ini, or "other"] causes "blocky-ness" like this. I have tried turning off all depth of field and lens flare and changed TAA for FXAA.

...yes, I put the ini file to read only so it wouldn't change back.

I noticed this effect on luggage caught in the sunlight too. I really want get rid of it if possible. Pic needs to be full sized to see issue.

http://cdn.overclock.net/f/f9/f9529d30_2015-11-21_00005.jpeg

Are you running the latest drivers? Both AMD and Nvidia have put out drivers with Fallout 4 improvements. AMD's are beta but still.

What GPU out of curiosity?

358.91

GTX 980m 8GB

Do you mean the aliasing around the hat? That's Godrays. You need a high setting to not see that, but it eats FPS.

I already have it on high.

I don't think I can do ultra because I upped the ugridstoload to 7.

The only option is turn off godrays off,it doesn't really turn it off but what it does is uses what appears lower texture semitransparent then the high settings from what I can tell.

You still see the rays coming from the vault etc just not extensive,Godrays is a Nvidia implementation of Gameworks from what I read.