Comments like these make me wish for a good gaming PC.
You don't need anything too hardcoe (by today's standards) for F3 even if you mod it up.
But it's worth it, even if it is the most complicated modding process I've ever experienced. You get enough mods like this MMM, FWE, and Weapon Mod Kits - it feels like a completely different game. It's a bit addicting though - now I got those working right I want to add GNR More, Zeta Crew, and DC Interiors.
OT- Same for me: I thought the failed experiment was gross enough in the Vault but when you got one chasing you down it's a little nauseating. Centaurs make my skin crawl too but not as much.