I think there needs to be more larger quest mods in general. Not a simple single quest, but I'm also not asking for massive new lands mods.
Just a few quests that tie together and are fun and well made. As for your catagories:
I prefer serious quests. They can have humor in them, and I actually applaud well written humor, but a comedy movie in quest form type thing wouldn't appeal to me.
Quests of all 'scales'. Focus doesn't matter as long as it's well written and interesting in other ways. It can be helping some guy plant crops for all I care, if I have an interest in doing it I'm all for it.
Again, both. Mystery is good, if well written, and straight forward can be just as good if well written. If it's a really dry 'Go here for no reason', 'okay now go here for a single line of dialogue for no reason' then it would svck. But liven things up and keep it interested and straightforward is just fine. However, a mystery quest that's pointlessly confusing and hard to follow can be very bad. you want to gently pull the player along, not speed away down the road without them.
Combat is fine. A quest that's entirely combat would be hard to keep interesting without really good design. Same with a quest that's nothing but dialogue. Again, if well done either is fine, I suggest a variety if you are adding more than a single quest. Change the pace and mix it up.
Happy and sad endings mixed, again. Either is okay as long as it makes sense and feels fulfilling.
I prefer conclusive, unless intentionally left open ended. If it's a cliff hanger and you'll be making an expansion for your mod that picks up where you left off, that can be good. If it just pointlessly trails off into an open ended nothingness and leaves me with an empty unfulfilled feeling though, that's very bad.
For subject matter, get creative. Again as long as the story is interesting and well written, and it's a fulfilling experience it can be about just about anything you can imagine.
Hopefully this helps. 