I always find myself carrying way too much stuff, mostly weapons, but I don't trust putting it in anything because of reseting, so I end up walking around the wasteland with 200lbs of weapons and armour I don't use, to the point if I took off my power armour I would be overencumbered and that svcks. :/
Also, I have a problem with ammo, I never have enough to defend myself and always end up switching weapons mid-battle.