Mine will probably be strip down to my underwear
and head the opposite direction than they want me to go.

Squint...

The first thing I'll do is follow the main quests for my first play-through

Check out the other conversation options with the robot of course.

Yeah, this sounds sarcastic, but you know everyone will do the same.

I'll head directly East through Quarry Junction, slaughtering each and every Deathclaw who will not bow down until I reach the Strip and impose my righteous claim on the Lucky 38 tower, crushing the usurper, Robert House, and eventually ruling the Mojave.

Oh... wrong game. Well, I'll probably cry and crawl back into Vault 111.

Find a mutated deer/elk whatsit. Kill it. Eat it.

Provided it made it past concept art that is.

Check out the surrounding area, look for better weapons... Check through my pipboy, play a pipboy minigame, Look around at the scenery... then maybe head to Sanctuary hills.

I'll do what any rational person would do finding themselves 200 years into the https://www.youtube.com/watch?v=yk7IDVzLiQo.

Finish my first beer, then crack another in celebration of course.

I'll stare in shock as everything I had known and loved is but a charred remain of what it was.... how are these skeletons bleached? How long have I been in that damned Vault? I need answers and I need to find my wife and Shaun..... Something tells me I need a gun too.

Search for my Ghoul wife.

"My god... Is this Chicago? It's.... it's all gone. My friends, my home... Even that soda shop where my wife and I met. Shaun... I'm so sorry. How could I have brought you into this world, only for you to be taken out of--- OOH, a gun! Shiny! I'mma shoot things!! "

pick up everything not nailed down in the houses, try to find a merchant, then find some where else to loot!

Look for something that isn't a vault suit to put on, probably.

Explore.

Make my way around killing stuff, stumble into a quest line and roll with it.

Find dogmeat. Proceed to pet it. Repeatedly.

Then find a tennis ball or similar so that I can watch Dogmeat bring it to me.

Put on sunglasses.

Yep, explore. Get used to how the game works, have a look at the new pipboy for a bit and then do whatever the hell I want. A weapon would be a priority assuming you don't have one when you're out.

After I get the dog and talk to the robot, I will of course loot every house on the block and then frolic away in some random direction.

Go to house and stare mournfully at the empty crib, naturally.

After 200 years on ice I will want a hot shower.

Based on the previous games I've played? Follow the breadcrumbs to the first quest hub, getting distracted by Random Loot! along the way.

Oblivion - well, it was hard to be distracted by anything else, when there was that great big Imperial City right up the hill....

Fallout 3 - head towards Megaton, oooh, is that a school full of raiders?

Fallout NV - head towards Primm, oooh, is that a shack/checkpoint full of powder gangers?

Skyrim - head towards Riverwood, oooh, is that a mine full of bandits?

Wheeeeeeeeeee!

Find a laser gun, because firecracker-powered slugflinger tubes are obsolete.

Kill something with extreme prejudice