Well, we do know that Oblivion had 21 skills and Skyrim will have 18. We also know that Mysticism, Acrobatics, and Athletics were removed. So unless there is a new skill being added (possible, but unlikely, I think) then the Hand To Hand skill will be in the game. It has also been said that every skill will be useful and relevant. (I think we've heard that one before, but I still want to believe it.)
We also know that every skill will have unique Perks, and have seen in past games that Perks can mean special moves. Fallout 3 had Paralyzing Palm, and New Vegas, while not a Bethesda game per se, had a number of special unarmed moves with their own animations, such as the Ranger Takedown and the Scribe Counter. These were fun to use in my experience.
Hopefully Bethesda will take a page from Obsidian's book and make cool moves available via Hand To Hand Perks.
Of course, nothing is confirmed. But this seems reasonable to hope for