Endurance was my dump stat for 3 and NV, and unless stuff changes radically it will probably be my dump stat for 4. Strength is nice for the carry capacity, damage and melee attacks, Perception can never be low because I love energy weapons, Int is always close to max for the skill points (though that might change for this game), Agi is nice for more time in VATS, and luck is sort of a secondary dump stat, but I don't like it being dirt low.
Having a low endurance doesn't do much other than give you low hit points, which I like as it ups the difficulty a bit and feels a bit more realistic (soaking up hundreds of bullets just feels a bit too cruse control for easy, ya know?)