There would be a sudden lack of toilets.
As would happen with children (Though maybe the lack of children can be explained by the fact that at some point in time, everyone lost the ability to get naked, and with no new children being born all children grew up.)
However, if the Elder Scrolls was real, I think we'd all die, because in real life you can't reload and save.
Or maybe everything would just vanish into a puff of logic when you realize that the Elder Scrolls world can't possibly exist in real life.