Well, I am making a new character using FWE's alternate "start". I'v decided to play as a sneaky "assassin" style character. No real moral compass or anything. She explores, salvages and won't take another thought about putting a .50mm round through the head of someone she even remotely suspects of having ill intentions towards her. I plan on Sneak and Guns for her tags, however I need an idea for a secondary weapon skill. Any suggestions?

Explosives maybe? If you're going to be sneaking around, placing mines could be useful if you expect to be detected, or if you want to lure people into a trap.

Didn't we discuss this exact topic a while ago?

Anyways, how about melee weapons? http://fallout.wikia.com/wiki/Shishkebab_(Fallout_3) would make a pretty good assassin type weapon.

Melee, Shiskebab baby.

How is Unarmed vs Melee?

Unarmed, with all three iron fist perk ranks, and with Paralyzing Palm, means that you are king of the universe. That combination is just that powerful. If you use VATS, you get more chances to hit with smaller weapons like spiked knuckles.... with the power fist you get less. Different varieties of power fists are cool, like the Shocker. Stock up on your endurance. You can successfully block, with little damage, when you go outside of VATS. When they recoil, get some good punches in. If they have a projectile weapon, get all up in their faces, and then they freak out and stop firing for a few precious seconds, more whacks for you.

You sir, made me go Unarmed XD