Mine right now is a almost totally modded out .44 cal. Does 129 damage with my small guns perks, and 3.5 X that with my ninja skills. Got a laser gun that does the same, but uses up about 2 X the APs.

My "go to" "gun" is Pickman's Blade.

Otherwise it would have to be the Deliverer or Overseer's Guardian but mostly Pickman's Blade.

Rockville Slugger, been using it from teens to current level 41 and still going strong due to upgrades. Halved AP cost is incredible

Gauss Rifle

Depends on which character Im playing, current gunslinger playthrough I shift between Deliverer and Keloggs gun

A rebuilt version of Overseer's Guardian.

Never ending assault rifle, fully tricked out with a reflex sight (normally I snipe but when things get close, 5000 rounds and no need to reload.....)

I named her -Yvette. We're gonna get married once I convince the Director at the Galleria to loan me some parts...

Sentinels plasmacaster or a combat rifle modded to .308

Spray n pray .45 submachine gun with explosive rounds for most stuff, i don't even have to "hit" the target and its dead, lol then my .50 suppressed Sniper with explosive rounds for stealth one hit kills.

Semi auto combat rifle that I modded for damage. It's not flashy but it kills anything and ammo is plentiful.

Always keep the Deliverer equipped.

Yeah, nothing says, "Stop right there!" quite like a gauss rifle. I find it ideal for the big nasties.

Another weapon I like is an assault rifle that I picked up somewhere early in the game. It has a +10 plasma damage attribute that is wonderful for farming nuclear material.

I wasn't too sure about the Combat Rifle when I first picked it up, but I'm glad to say that doing so was an excellent choice. It's a great weapon with a solid balance of damage and fire rate, has a great mag size, and can be customized to fit a variety of roles, just like the Pipe Rifle. I also really like the fact that it readies almost instantly; when you pull out the 10mm pistol, for example, your character racks the slide, and with the .44 pistol, you give the cylinder a spin. Neither of these can be interrupted, and you can't fire the weapon while the animation is playing. The Combat Rifle doesn't have any animation when you pull it out; it's just up and ready. I've currently got it as a Tactical Powerful Cobat Rifle, with a Powerful Reciever, a Long Barrel, a Medium Quick Eject Mag, and a Reflex Sight, and it's doing great. I just went to Jamaica Plain at Level 17 to get Sal's Combat Armor, and didn't have any issues. I could take down each of the Feral Ghouls there in no more than a couple of shots.

Easy... The "Explosive Shotgun" .... in 3 to 4 well aimed shots, it'll put down any DeathClaw... And it just obliterates anything else... Hope they don't Nerf it.

In Stealth mode... "The Deliverer"

I have 4 different guns for different uses... Explosive shotgun short range detected, silenced 10mm for undetected, .50 sniper for long range undetected, gauss rifle for long range detected and powerful foes like sentry bot. Suppressors on all of them for the 6.3x sneak bonus.

My custom DB shotgun, "Dragon's Breath". Originally a Legendary drop that did fifteen points of fire damage.

I gave it circle reflex sights, a full stock, a muzzle break, and an advanced receiver.

"All the damage, none of the recoil!"

Also in my favorites is my Marksman's .50 Cal Sniper Rifle. Originally just a short hunting rifle that spawned with a .50 receiver. I gave it a full length, ported barrel, a marksman's stock, and a medium scope. Haven't thought of a name yet though. Suggestions?

I always have on me a combat shotgun (semi auto) equipped with a bayonet. I named it "Street Cleaner".

I so miss desert eagle tho (preferably .50 cal).

My much modified Plasma Rifle. I love staying ranged and I love gooifying people.

Back-up is an advanced Shotgun.

My primary weapon is a fully modded combat rifle chambered in .308 with a short scope on it.

I also carry a .50 Recon Sniper Rifle that's fully modded with a long recon scope, marksman's stock, etc. and a fully modded advanced combat shotgun. I also carry Kellogg's Pistol with me, which is also fully modded, but I don't use that too much. I may just stop carrying it so I can shed the 6 pounds or so. I recently got the Deliverer, so I might try that out as a sidearm as well. It's got a suppressor, which is nice. I might equip my sniper rifle and combat rifle with suppressors too and just go full on stealth.

Since I found a legendary deathclaw matriarch who happend to be carrying an Instigating Gauss rifle, I never used another weapon after fully tricking it out.

I have a really souped up 10 mm pistol with a good firing rate. I love that thing.

Mine is a "Mighty"(+25% damage) Laser Musket modded fully with 6 crank. Dubbed it the "General's Musket" and it works for sniping, vats, or close quarters. Having a lot of fun with it.

hard to decide, right now I carry around the following )all of which have been upgraded) :

Furious power fist

deliverer

overseerer's guardian (which I'm considering making a 38 because I have 1,000s of rounds of it (and I burn through ammo on that gun so quick as it is).

old faithful (turned it into a sniper rifle)

and an explosive combat shotgun.

I have a vats enhanced assault rifle, and a plasma rifle that ignores 30% of the enemies defenses which I am considering playing around with, just running low on supplies to mod them right now.

Ever since I downloaded a mod that made it so that .50 doesnt svck major ass... My violent, suppressed .50 sniper rifle is my go to weapon.

.44 Magnum called "Nora"