I don't see why this needs to be in Skyrim General Discussion, since it's not like it's about how the saving system should work in Skyrim, or even a subject that only applies to Skyrim.
But in any case, the method I'm currently using for Oblivion is to have at least three manual save slots in use at any given time, one I use when saving in interiors, one I use for wilderness locations, and one is for in walled cities, I've also used that one for Oblivion gates. I also regularly make streamsaves using the Streamline mod, primarily as a substitute for quick saves. Since the mod keeps multiple save files (15 by default, though I'm pretty sure you can change it using the mod's customization options if you so choose.) and cycles between them before overwriting older ones, this means that I have many older saves to go back to if I mess up or some sort of horrible bug breaks my save.