Well I don't have many great ones yet, but I'm hoping to get a few over the next few weeks with my current character. I'd love to hear yours though.

On my old playthrough I remember seeing some raiders far away and without aim or thought I shot my rifle to get their attention and the +30 exp come up on the side. I lol'ed a little at that one.

On my current playthrough I got 3 raiders with 1 grenade. The slow motion vats animation was the best I've seen yet. I was in awe. The three raiders all shot up in the air in 3 different directions with their limbs slowly detaching, almost synchronised with each other.
VATS is genius and to think I didn't used to like it.
Not great I know, but I'm sure you guys got some good ones to share

I once shot a Super Mutant with a spike and it blew it's head off and stuck to the wall.

I exploded the pants of a Super Mutant Brute. Didn't know they had pockets, wait... that's not a pocket!!
Knowing about a certain spawn point for Talon, I mined the entrance of a certain place I was visiting. When I came out this is what I heard:

"Well, if it isn't the little saint from the vault....."
(second Talon guy) "OH SHIIIIIIIIIIIIIIIIII......"

Boom. Hat trick baby.

Some of the best I have had are a missile launcher with a low big guns skill.
It is amazing what you hit on the other side of the creature when Vats only gives you a 25% chance.
I have had missiles scream by raiders and deathclaws and miss them over the shoulder by a half an inch and take out others down the road. Lol.

The best shot I've had is with my hunting rifle mod. It allows the distance of the shot to be double that of the vanilla game.
My bullet must have travelled throught 4 sets of trees, missed every branch and hit the Robobrain that never even knew I was there. It was so cool.

Some highway, full of buses and cars, great gunfight with raider. One threw a grenade which didn't make it over the bus....10+ cars went up in the are along with 5 raiders and a Lone Wanderer...EPIC

Perhaps scripted, but I had a laugh out of telling the one NPC to go and try and reason with that nutcase that just spat out one liners ("Your mother and my mother hung up laundry around the mulberry bush" or something like that). Of course I reloaded a save after trying it, but I thought it was funny none-the-less, despite the NPC knowing the hazards.

Sweet revenge when I one shot VATS a certain colonel lacky's head off with a combat shotgun and watched his headless body limply fall off the catwalk in slow mo.

Favorite one I've done is perhaps was at a certain Raiders "foundry". Sneaking through and seeing the cage, I lob a grenade at the generator to unleash the Super Mutant Behemoth on the Raiders. After the mutant was finished taking care of business, slaughtering all the Raiders outside, for some reason he ran back into the cage and just stood there with his back to the gate. So I snuck up to the gate and had a load of frag mines to use up (I needed to lighten up my encumbrance anyway). The Raiders had already taken down the Mutant Behemoth down by half, so I put down a pile of 20 frag mines, hoping that was enough. So once the pile was down I moved back to a safe distance still hiding, and take out my .44 (wanting to make sure those mines go off when they're suppose to. I've had some that were delayed) and then take one shot first to alert the Behemoth to where I was. Then of course I had the scope aim ready at the pile of frag mines and shot one of them just as the mutant ran by the pile. I was happy to find out that 20 frag mines were just enough to finish him off. KA-BOOOMB I didn't have a Fatman with me.

Taking down several Enclave helicopters with a mini gun is kinda fun.

Sneaking through Paradise falls and picking the heads off of the slavers with Lincoln's Repeater.

Edit: BTW, anyone know why you lose karma for "exploding the pants" off of a Mirelurk King?

My best was taking out a Talon Co. Staff Sargent who was in the the dish of one of the SatCom's. I was on the ground, at night, using the M79 Grenade Launcher. By lining up with the IFF, I was able to take him out with about five shots. Really fun to watch the grenades arc into the dish.

Ok I have a very random kill that happened the other day lol.
I dunno where he came from as I had not even started the MQ yet at this point. I heard gunfire and I checked in vats and it was an Enclave Soldier. I was like wth. So instead of leaving him I decided to try and kill him. After 3 unsuccessful vat shots he started pounding me with his laser rifle( it could of been plasma can't remember) so I hid lol behind some rocks letting my vat points regenerate. Take out my grenades as he gets close an lob 3 grenades at at him in vats. The first grenade sends him up into the air about 200feet? Of course my character kept throwing grenades but the 2nd and 3rd didn't hit as the guy is still rising into the air! I'm like WTF is happening? Anyway after rising a bit more he finally started to fall and I just watched as he fell to his death.
Rifle and hellfire armor thank you very much lol.
Must of been a glitch. But was quite random.

Lol that's awesome. That glitched Enclave soldier usually kills me. I have rocketing Deathclaws and robobrains. It's the physics... Sometimes my deathclaws land and start coming after me, and then when I think I'm about to die, they shoot off again. Any companions kinda freak out when this happens.

I forgot his name, but he comes with the Broken Steel DLC. I believe it's the quest where, the caravan was shot down by these bandits and you pick up a note from one of the caravaneers. The note tells you the "password" to their group and where they are meeting. Wilhelm's Wharf. So I went to Wilhelm's Wharf and I told them the correct password to their group of bandits, so I was officially a member. Well we walked up to this car and I started shooting at it. It got on fire and the leader's men, were pretty close to it. The car blew up, and flipped and blocked the leader from his members, with the members on the opposing side. The leader looked straight at me, as his members were blockaded and I shot him in the head and ran off, before the members could see me. Well I looked back and it seemed that the car explosion detonated another car explosion BEHIND the car that exploded, and the blockaded members, were blown away. I went back and it was tragic. And the thing is, it went by so fast. Aha.

Shooting car>explosion>blockaded members>shot to leader's head>ran off>another explosion to kill off blockaded members>ran back> VICTORY!


It was actually a perfect storyline moment. He didn't even expect the shot. Aha. Gotta love them NPCs...

I was lookin' to do sum recruitin' for Paradise Falls. I was over at Canterbury Commons & didn't like how Dominic D'Ellsadro was talkin' ta me so I shoot him with my mesmetron & something weird happened. He didn't become docille like he was supposed to. Instead he starts shootin' at Doc Hoff & his Caravan Guard way out in the distance. I didn't even know Doc was out there. Doc's Caravan Guard starts shootin' back at Dominic. I don't know if Doc was firin' back or not. I was just standin' there tryin' to figure out how to put this slave collar on Dominic before he goes & gets hisself killed. Before I know it Dominic is dead. I pick up Dominc's gun & strip the very clothes he was wearin' off his back & then sell them to Doc Hoff. Best part was that no one in Canterbury Commons even noticed. Anyone seen Machete? I got a nice necklace fo her.

Do you know that drive in movie theater place near Tenpenny Tower? Well its a raider base and every playthrough I run in, throw one grenade, run up to a ridge, and watch the magic happen.

Everybody dies in a series of nuclear explosions, its so satisfying.

Well, this is quite easy for once.

Walking alongside Liberty Prime, I let the robot go fourth to clear the way while I pick up the mess.

A random super mutant comes out of no were, so first reaction to it shoot. After shooting, & looking down the road I notice something blow up, then launch towards me.

This was a car. I did survive the impact oddly. Though the Enclave solider behind me who was hit after me, well lets just say it did not end fell for him/her.

That was the funniest kill I probably was evolved in.

I know this is the fallout three forum but my funniest was in new vegas. Powder ganger threw TNT at me, I shot at it with a flare gun and it bounced back and hit the powder ganger then blew him to bits.

Whenever I get a headshot that makes a super mutant pirouette like a Ballerina into the sky. Always gives me good chuckle.

Well I was walking through the old Springvale school lookin for somthing to shoot (this was when I just left the vault) I had only a BB gun equipted and a raider was stuck in a wall and a desk, I just kept shooting and he wouldent die. I stopped shooting and I walked up to him and he just *Exploded*. Quite funny at the time.

There's something seriously satisfying about blowing up a Enclave vertibird with A3-21's plasma rifle. Even better when you have time to take out two or three of them.

Heavy mods in this one.
I was bored out in the wastes, Placed a nuclear missle beacon, waited a minute and BOOM!
Hits an orca that came out of nowhere and blows up mid air with a pretty floating mushroom cloud.

My most memorial & favorite fray was sneaking up on 7 raiders throwing nukacola grenade @ the middle one using vats it took all of them out I was just in awe as the body were shredding as the flew threw the air. It was the biggest mess I ever made & most carnage and most unforgettable. Funniest was accidently learning that u can reverse pickpocket mines. after exiting a tunnel(crouching...my usual habit) some regulators were waiting but facing away in a panick I pressed my buttons & entered pickpocket mode I decided I ******* anyway so I decided 2 experiment I thought wth I'll c what happens if I put a mine in his pocket (best decision I ever made) as he ran away he took out one of his buddies & badly wounded the other one who made a poor decision by hiding behind a motorcycle which caught fire from the blast & exploded which I heard while i was still hiding @ the bottom of the steps(ultrajet place). Finally I went up expecting some action but they were all dead as I inspected & figured out what happened i was like holy **** I'm a bad*** of course I was just lucky though

I'll never forget the first time I saw a teddy bear (from the Rock-it Launcher) obliterate a super mutant's head.

Carefully placing as many frag mines near Tenpenny as I can. Then save game. Stand back and pop him with a Bb gun. When he gets up...BOOM. Watch him fly into the distance. Hilarious.

I don't know about a funny kill but once I saw a Radscorpion glitched underground. I walked up to it and was like 'Haha, you can't get me!', turned around and I died. Karma's a 'you know what'.

I was walking around Georgetown (arguably one of my favorite places in D.C), and a mutant was on a ledge about fifty yards up. I realized he was using a minigun, and I needed 5mm ammo, so I decided to start fighting it.

I pulled out a hunting rifle, popped a round in his head, and he seriously flew straight up into the sky, and his corpse never landed.

I found one of his limbs about 5 minutes later on the next block. I looked all over the place and couldn't find his corpse.

I seriously laughed for about ten minutes.

I love watching an Albino Radscorpion take out a Talon Patrol.

I only have done this once but I managed to explode the pants on a Supermutant Master.

Both of these events were very satisfying.

Funniest kill I ever had, was probably when I missed a ghoul in VATS and it hit the ghoul behind him decapitating him Good times