i just want to know what is better to play with?

HDR with Anti-Aliasing and Anisotropic Filtering enabled through your GPU Driver setup.

Depends on whether it's for gameplay or screenshots. IIRC the AA settings of your GPU driver won't apply to screenshots.

I do not like HDR myself. It makes the screen much too bright for me, and the colors feel washed out. So I leave it off. I always have some AA turned on.

Will that work with nvidia cards? I didn't think they could run both.

I'm unsure of Nvidia, but I know that the Catalyst Control Center allows for both. I don't see why it wouldn't though.