Well I know we still need to see, play and love Fallout 3.
But if it rocks and the DLC rocks.
Whats the best location for Fallout 4?
Personally I love to see it take place in the Chicago-waste.
Primarily because we all know the main Chicago vault was outfitted with only gangster movies, books and mob related TV Holodisks.
(Presumably this was to study the effects of lawlessness & gang mentality on the human psyche.)
This would leave the Chicago wasteland populated primarily by 3 rival gangs, a lame squad of Untouchable do-gooders and a shadowy group no one knows much about.
I just think with the right people working on it you could make Chicago a true 1920's gangster paradise that those wannabes in New Reno would drool over.
After all, the Chicago vaults were big enough to store plenty of vehicles in.
What would gangsters do without car chases after all...