Maybe Chicago or NY? Or maybe Atlanta? I agree that nothing could really match the power of the post-apocalyptic ruins of DC with all of its monuments and significance to the country.
As for a timeline, I would personally love to see a scenario where the player is born, is toddler, child, etc. before the bombs fall. You could see how the world is and get a feel for it, maybe even see part of it, before the nuclear holocaust. Maybe your family has Vault-Tec vault reservations, but something goes wrong, and you and your father are separated from your mother and a sibling. You manage to take shelter in a home bunker or conventional fallout shelter, but your father dies. Maybe you get raised by a Mr. Handy. Fast forward 10 or so years, and we get to experience the Fallout world in the beginnings of its post-apocalyptic stages, with a decade being enough time for small settlements or groups to form.
Main quest could be trying to locate your mother and sibling to see if they survived. You don't know if they made it to the Vault or not. You were too young to remember the Vault the family had reservations for. First stop - nuked home. Maybe you find out certain neighbours looted supplies, papers - you start tracking them down, etc.
Anyway, that's what I think would be cool. Still unsure of a location though.
No, the land would be too radiated to survive. As far as i know, everyone in the wastes is decended from people who got into vaults, or were extremely lucky when the bombs fell and had their own shelter
For some reason I think it would be cool for it to take place in Washington (State), Or the Seattle area.
Maybe it's because I live there though...
Yea, set it in the PNW!
I'd love to see the Space Needle standing around a bunch of crumpled buildings