The entire boot of Italy, man... -The southern island of
Sicily could just be BAD, and the only stuff you hear about it in the beginning are rumors of people who have gone there to work but have never come back, or people who have come back with limbs missing and such. It could just be a rumor mill until you take a rusted steamboat out there to do some work for an enemy organization (Raiders, Slavers, Mafia Family?) The mutation there could have been really bad, as it was the site of a new nuclear test for U.S. or China or something, and the animals that are mutated there could just be hellish and frequent...So the enemy organization sends people there to do all of the work, to kill them, etc.. (Kind of like the Steelyard.)
-Then, lost underwater, if you found a scuba suit (I believe there is a mod for it, hehe,) is
Venice... You could search through the old buildings that are being lost to the water, maybe find some treasure? A clan of people who take refuge in a building that has not been engulfed with irradiated water, and have no way of getting out? A clan of people who still think it is before the war? A cult? Hehe, the possibilities are basically endless. Exploring Venice would necessitate the need for some mutated underwater enemies, I'd say...As well as a schematic for an underwater functioning weapon.
...Getting myself all excited..
-Pip