I also like places in the center of the map, I don't like to feel walled and have few directions to go, Whiterun will be at the heart of Skyrim.
Whiterun:
http://www.elderscrolls.com/skyrim/media/conceptart/whiterun/
Of course I don't know if these will be the main cities, but based on the map of skyrim showed in the GI video, I think they will.
Please tell us what city you think will be your favorite and tell us why! I really wanna know some exciting new things or different views about the cities.
More info about the cities in Dragonbone's thread:
http://www.gamesas.com/index.php?/topic/1165975-information-on-game-locations/page__p__17152464__fromsearch__1#entry17152464