What Dalek said.
Yes, it would be realistic in some situations, but it would make the game incredibly easily, and would make the entire lockpicking skill useless, as those 3 perks would be more desirable than spending 100 points just to open a Very Hard lock. Besides, the only time I could see explosives being a viable option of opening a lock is with doors. Anything else and they would completely destroy the contents.
IIRC, the FOOK mod for Fallout3 had a great gimmick like that
anyone could use explosives to blow a lock, iirc? but, the power of the explosive, and chance to DESTROY whatever was inside versus the strength of the lock, was linked
so, a Very Hard lock would need a Bottle Cap Mine or stronger to have decent chance of working, but also, increasing chance of blowing what's inside to junk
thus, it was very balanced and fun