While I don't understand you never playing Fallout 3 again just because of that, I agree that was a very undescriptive thing to say when looking for someone. That's like saying "I'm looking for my best friend, a woman, have you seen her?" or "I'm looking for my brother, he was born a capricorn, have you seen him?"
But as stupid as that one little line was, Fallout 3 is still a great game and has so much better lines then that one.
And Holy Assassin, I can't think of a single middle aged guy who goes to Moriarty's Saloon. Except Jericho, Mister Burke, and of course Moriarty.