You could do it, maybe
Ghoulifacation is a full body cellular change, and you would need to preform a complete reconstruction of their biology without killing them.
It would be equivalent to turning a cat into a dog with genetic engineering. Or perhaps modifying a horse into a chimpanzee, why not turn a fish into a tree, all are the same type of procedure you would need to develop to turn a ghoul into a human specifically.
Super mutants are created as an accident, they were not the goal, genetic changes resulted in unexpected results. The scientists never set out to turn humans into super mutants, they set out to turn humans into something else. And that goal is super easy.
Sure you could do it with extensive genetic reengineering, cell transplantation, heavy dosages of life support, and drugs, but it would require so much effort for no legitimate purpose.