Is there supposed to be a way to tell Yes Man a certain group is hostile towards you? I shot up Gomorrah, and the quest instructed me to tell Yes Man the Omertas are now hostile with me, but when I talk to him my only option is to ignore them, and I don't want to do that because they're bastards.

Weird. When I got that instruction, the dialogue option appeared for Yes Man.

Don't take this the wrong way, but did you make sure to scroll through them all? As I recall the "I hate them now" option was at the bottom of a long list of options. I almost didn't see it myself since I'm so used to all the options being immediately visible.

I don't blame you for asking, but the list of options has become very short. The Omertas are the only group left. The Boomers support me, the Khans left, and I ignored the BoS and White Gloves.

As an aside, according to the wiki you should be able to change your opinion of a group after the fact, but I'm not able to do that with the White Gloves. I don't know if this is true, or if it is, whether it's a related problem.

Also, to bug test, I tried a much older save, where Yes Man is still in front of the Tops, and with mods off, but still the same problem. I've now posted it in the software issues forum, but I guess I'll hope against hope that someone knows of a workaround.