The potions and enchantments are so in depth, that I never find a use for them in game. The only potions I actually use are the restore health potions and restore fatigue. I never find the need to "fortify speed 10" or "disintegrate weapon 20 pts" etc.
And the enchanted weapons were cool, but needing to charge them by finding soul gems and trapping souls was just too much for me.
I am not by any means wishing that Skyrim be dumbed down, I love an in-depth rpg. I just mean that maybe the different effects could be made more useful during combat.