Well i don't know if anyone noticed but in fallout 3 some of my auto saves deleted when i killed someone with good karma
What you are experiencing is a corrupted save. Happens when the file is written over too many times. Not everyone has this problem, but it is common enough to say this:
Never Rely on An Autosave. Never Load an Autosave. In fact, it is best to turn off those features. However if you do use them, back them up with Manual Save slots. The more the better. I cycle through 10 of them, archiving or deleting after they get written over 10 times or so.
Steam Cloud will offer remote storage of your Autosaves and Quicksaves. Not sure how that mechanism will work. Does the autosave get uploaded each time it is made or does it get uploaded at some point after it is created and how much of this process is in the background and how long will it take to upload 1 to 5 MB of save file each time it does it. And, if you go in and out of a cell, will the Autosaves get mixed up in the transition from off line storage to on line storage.
Me, I am going to be disabling the Autosave Features and not allowing Steam Cloud storage of my saves.