Absolutely. My strategy guide for Fallout New Vegas is so beat up that if I sold it used, I could never say Used - Great Condition.
I wouldn't sell it though. I got so much more out of the game and the sheer size of it shows you how much there is to the game...and I really haven't come close to reading it all. I love the maps and the descriptions of things I can find, etc. It has a few errors but that's to be expected with something this big and in conjunction with the great Wikis we have online, it just makes it more fun. I try to not look first but then if I get stuck I don't have to be frustrated...I can find the answer I need and move on. In subsequent games, I can find and do extra things I skipped or missed the first time through. I never plan on doing everything the first game - it gives me that re-playability.
And I WISH I could find an Oblivion Strategy Guide for an affordable price but the price on it because of its collectability is just too high for me. I'll get guides on release day now.
So, short answer....YES!