First, and most playthroughs will most likely be Inspired by, and loosely based on the fellow in my avatar (I call him Floyd Barrett). I long ago, gave up all hope of trying to actually get my Fallout characters to even remotely resemble him, so I mostly just go for the mental aspect of it.
One of my favorite New Vegas characters was based on a fictional character from the song Arnold Layne. He was also named that too, unfortunately, he became the victim of a corrupt save. Subsequent attempts at recreating him were unsuccessful. I was able to recreate the face, but the magic that made him special was gone by then.
Maybe I'll try Arnold again in Fallout 4. Who knows, maybe I'll get lucky and feel that connection again.