I tend to try and keep this in mind, at least until the game comes out and we can see for ourselves:
1. Just because certain skills are removed, that does not mean that the function of those skills is gone. Mysticism, running speed, and athleticism are all featured in the game, they are just not under the same labels.
2. While attributes themselves have been "removed," they are not actually gone. The functions that they served will likely be entirely preserved in Skyrim, simply not called "attributes."
3. While spellmaking may be gone, the most desirable effects of spellmaking will remain (such as ever-increasing spell strength and changing targets or effect types), while the undesirable effects do not.
4. While classes themselves may have been taken out, there's nothing that classes ever did that you can't still do in Skyrim. If you want to give your character some skills and experience at the start of the game to represent his/her past, you can still do that by boosting some skills or "attributes."
So just try to keep in mind that each of these things was never more than a fiction, an illusion designed to represent something else. Now that "something else" has been added to the game directly, so that we don't have the clunky mechanics and spreadsheet numbers that build our characters, we simply have character.
There isn't anything lost by removing these things, the function that they were intended to perform is still there, but better and harder to see. This, friends, is superior.