If actions are voiced it will get extremely annoying. As in Far Cry 3, where Jason whines "Eww, gross!" every time you skin an animal (yet never questions slaughtering dozens of endangered species, or hundreds of people).
A voiced protagonist reduces replay value for me. I played Mass Effect through twice: one good Shep, one bad. I couldn't take sitting through all the cut scenes more than that. It's more like watching a movie - which is the trouble with modern game design. Developers want their games to be "cinematic", instead of free-flowing unpredictable video gameatic.
Fallout 4 will probably be a game I pick up late in a Steam sale, because I doubt I'll get much replay value out of it.