I voted "maybe", flamesuit is on. :flamed:

I had a character in Oblivion whom I tried to use H2H with, like he started out as a pure H2H character. What throws immersion for me is ...what happens when he gets attacked by a big 2-handed sword, or even an axe? Sorry, I just can't buy somebody blocking any weapon bigger than maybe a daggar without severe repurcussions.
That being said, it would be an awesome skill to use
if Bethesda does it right this time. A H2H player fighting an NPC who is also using H2H makes sense to me. Blocking a greatsword with just bare hands does not.