» Wed Jun 16, 2010 2:50 pm
Nobody really knows what the cause is. Speculation is that it has to do with the quest "Come Fly with Me" but at least a few people who have completely avoided that quest received the same exact error. Still others have been playing for >30 hours of played time and not seen the glitch at all, so it appears somewhat random in its appearance. Nobody's sure at this point.
It is almost certainly nothing to do with the DLCs, however. Many of those with the glitch didn't even install any DLCs, and even for those who did the error makes no sense. Why would not being able to load a piece of armor, a weapon or two and some misc. other stuff cause all of your save files to spontaneously become unplayable? Even with fairly bad coding in that area, losing a few items wouldn't kill the whole game, and as the followup error claims that the game can't reach your hard drive/memory card with the save game on it (which virtually all the time is a complete lie) I'm thinking that there's a very, very good chance that the DLCs are fine and have little, if anything to do with the real cause. The problem is likely in the game's core coding (perhaps with the coding for saves and how the game finds/loads them) and not with the DLCs.
If you want to be super careful you may be slightly better off not loading any DLCs and avoiding the aforementioned quest for now but again I really doubt that's the issue since people who have avoided both have still hit the glitch. At this point my best advice would be to not get overly attached to your character just yet and try to space out your play time so you don't get a whole ton of hours in right off the bat, else you may find yourself without any saves until they find and solve the problem and believe me, that's no fun.