I would be Colonel Autumn and do the following things:
- Assassinate President Eden and rule over the Enclave as a military junta until things get better.
- When capturing the Lone Wanderer, beat that damn code out of him/her. If s/he wishes to co-operate, allow it.
- Capture Wasteland cities instead of blocks of sand with my vast army, and possibly train Enclave fanatics for a Wasteland militia to fight alongside Enclave troops
- Abandon the FEV, forget the Purifier for now, attack the Citadel.
- If and when the Brotherhood is gone, force the remainder of Wasteland settlements to accept Federal Authority.
- Ban firearms from civilians in Enclave-controlled areas, except of the aforementioned militias.
- Exterminate dangerous genetic defects like Super Mutants. Do not massacre Ghouls, just send them away on the threat of execution to preserve local support. Too much mutated locals will be spared but sterilized.
- Restart Project Purity.
- Work to reincorporate genetically acceptable Wastelanders to the United States government, though make preparations for future eugenics programs to preserve Pure human DNA.
- When all of the Capital Wasteland is under my control, hold democratic elections (Wastelanders won't be allowed to vote, though). I will win of course, being the only remarkable candidate, but I need to prepare my people for the time I'm gone.
Sir if it was for people like you, then i would have joined the Enclave long ago (i actually believed your silly Enclave propoganda in the game, well until the point where i got shot at with a weird looking guy down in a basemant, with a evil looking helmet and armor, and high tech laser rifle. My my, wish i had some space in my inventory.