Yes... I do use followers, both vanilla and custom. If I use a follower depends on my Role Play, the story dictates if or who the follower is. Very few of my characters are "loners", I guess because I don't think along those lines. Even my Assassin, had two followers...travel companions, Belrand and a dog, they never went on "jobs" just to the city or nearest Inn. Thus they never go in my way during job's. Even one of my Vanilla Thieves used Lydia...just left her at an Inn or outside errrr keeping watch, it worked for me.
There are a few very nice followers with custom voice and AI, that can really be amusing and fun travel companions. Bishop from Skyrim Romance is a good "follower" though his personality would be abrasive to some people. Hoth ( stand alone follower ) is very amusing and has some great lines. Rayan, a very good follower, has some awesome lines, not female PC friendly really, better with another male as a follower or.. interest. I know there are also some great female follower's, I have not used any custom ones, as none have suited my character or story.
Everyone being different, I know followers are not for everyone... and that's fine.