they did, Bravely Default
as long as its a good game that I would enjoy then sure, I'd like it..
I am always up for a fun engaging game, spin-off or not..
It depends on how well a job they did with it. For example, I'd be over joyed if someone made an ultima 7 type game with the over head view and open gameplay, but I would hate having to draw a map on graph paper again. I don't have the patience for that anymore.
In terms of RE, I know nothing about the series.
In terms of non-canon spin offs, it depends on how it's handled. Yakuza: Dead Souls? Excellent spin off of the series.