I have two mods that might help you without modifying the aliens themselves. My Microwave Emitter Fix and Deathclaw Gauntlet Fix restore the "ignore DR" attribute of those weapons that does not work in the base game. As a result, those weapons become very effective against highly armoured enemies. For example, a sneak crit from the ME will disintegrate any alien in one hit.
However, if I recall correctly that only worked in VATS. My mod works the same way as the Point Lookout Hillybillies. They also ignore armor. Due to the way this is set up skill does not matter anymore, but VATS is not needed. It needs FOSE though.
When Nexus is up again just search Gauntlet Fix. The one with my name in the title is surprisingly mine